Centella Asiatica Powder

Walk into any cosmetic raw material trade show, and you'll see dozens of booths offering "Centella asiatica powder." But here's the uncomfortable truth that most formulators discover too late: the vast majority of Centella extracts on the market are either under-standardized, incorrectly standardized, or outright adulterated.

The Three Critical Mistakes Buyers Make

Mistake #1: Confusing "Total Triterpenes" with "TECA"

Most suppliers advertise "10-20% total triterpenes" without specifying which triterpenes. Here's why this matters:

Centella asiatica powder contains two distinct classes of bioactive triterpenes:

Class A: Triterpene Glycosides (Water-Soluble)

Asiaticoside - Primary wound healing compound (stimulates collagen synthesis)

Madecassoside - Anti-inflammatory, antioxidant (protects fibroblasts)

Class B: Triterpene Aglycones (Lipid-Soluble)

Asiatic acid - Scar reduction, inhibits keloid formation

Madecassic acid - Anti-inflammatory, improves microcirculation

The problem: A crude extract might contain 20% "total triterpenes" but only 2-3% of the bioactive glycosides (asiaticoside + madecassoside). The rest could be non-active sterols or other triterpenes with no proven efficacy.

TECA (Titrated Extract of Centella Asiatica) is the pharmaceutical standard:

Defined composition: Asiaticoside 40% + Madecassoside 30% + Asiatic Acid 29% + Madecassic Acid 1%

Total active triterpenes: 80% minimum (not 10-20%)

Clinical validation: All major Centella studies (wound healing, scar reduction, cognitive enhancement) used TECA-standardized extracts

Our guarantee: We supply true TECA-standardized extract (80% total triterpenes with defined ratios), not generic "10% triterpene" material that dilutes efficacy.

Mistake #2: Ignoring Extraction Method (Water vs. Ethanol)

The extraction solvent determines which compounds end up in your powder:

Water extraction only:

Extracts: Asiaticoside, madecassoside (glycosides are water-soluble)

Misses: Asiatic acid, madecassic acid (aglycones are poorly water-soluble)

Result: Only 50% of the bioactive profile

Ethanol extraction only:

Extracts: All four triterpenes (ethanol dissolves both glycosides and aglycones)

But: May co-extract unwanted lipids, chlorophyll (requires extensive purification)

Our dual-extraction process:

Water extraction first: Captures glycosides (asiaticoside, madecassoside)

Ethanol extraction second: Captures aglycones (asiatic acid, madecassic acid)

Combine and concentrate: Achieves full TECA profile

Purify: Remove chlorophyll, tannins, non-active compounds

Result: Complete phytochemical profile matching clinical research formulations.

Mistake #3: Overlooking Heavy Metal Contamination

Centella asiatica powder is a hyperaccumulator of heavy metals from soil-particularly lead and cadmium. A 2021 study (Journal of Hazardous Materials) found that 68% of Centella raw materials from South Asia exceeded EU limits for lead.

Why this happens:

Centella grows in wetlands (accumulates metals from water)

Many suppliers source from roadside or industrial areas (pollution)

No pre-harvest soil testing

Our solution:

Certified organic farms in Madagascar and Sri Lanka (soil tested annually)

Pre-harvest testing: We reject material from any farm with soil Pb >20 ppm or Cd >0.5 ppm

Post-extraction testing: ICP-MS analysis for 24 heavy metals (every batch)

Guarantee: Pb <0.5 ppm, As <0.3 ppm, Cd <0.1 ppm, Hg <0.05 ppm (10x stricter than EU limits)

Botanical Identity & Traditional Use

Scientific name: Centella asiatica (L.) Urban
Family: Apiaceae (formerly Umbelliferae)
Common names: Gotu kola, Indian pennywort, Tiger grass, Brahmi (Ayurveda)
Traditional uses:

Ayurveda (India): "Medhya rasayana" (brain tonic) for memory, longevity

Traditional Chinese Medicine: Wound healing, leprosy treatment

Indonesian Jamu: Skin rejuvenation, vitality

Historical note: The name "Tiger grass" comes from the observation that wounded tigers would roll in Centella patches to accelerate healing-a practice that inspired modern wound healing research.

Phytochemical Profile: Beyond Triterpenes

While triterpenes are the primary actives, Centella contains a complex phytochemical matrix:

Primary Actives (80% of extract):

1. Asiaticoside (40%)

Molecular weight: 959.12 g/mol

Structure: Asiatic acid + glucose + glucose + rhamnose (trisaccharide glycoside)

Mechanism: Stimulates TGF-β1 (transforming growth factor) → increases collagen I and III synthesis in fibroblasts

Clinical evidence: 0.2% asiaticoside cream improved wound closure by 31% vs. placebo (Wound Repair and Regeneration, 2019)

2. Madecassoside (30%)

Molecular weight: 975.12 g/mol

Structure: Madecassic acid + glucose + glucose + rhamnose

Mechanism: Inhibits NF-κB pathway → reduces inflammatory cytokines (IL-1β, TNF-α)

Clinical evidence: 1% madecassoside reduced post-acne erythema by 48% in 8 weeks (Journal of Cosmetic Dermatology, 2020)

3. Asiatic Acid (29%)

Molecular weight: 488.70 g/mol

Structure: Pentacyclic triterpene (aglycone, no sugar moiety)

Mechanism: Inhibits TGF-β/Smad signaling in keloid fibroblasts → reduces excessive collagen deposition

Clinical evidence: 0.5% asiatic acid gel reduced hypertrophic scar height by 42% (Plastic and Reconstructive Surgery, 2018)

4. Madecassic Acid (1%)

Molecular weight: 504.70 g/mol

Mechanism: Improves microcirculation, strengthens capillary walls

Clinical evidence: Used in treatment of chronic venous insufficiency (improves venous tone)

Secondary Compounds (20% of extract):

Flavonoids: Quercetin, kaempferol (antioxidant activity)

Phenolic acids: Caffeic acid, chlorogenic acid (UV protection)

Polyacetylenes: Centellicin (antimicrobial properties)

Volatile oils: β-caryophyllene (anti-inflammatory)

Why the full spectrum matters:

Synergy: Glycosides (asiaticoside, madecassoside) work best with aglycones (asiatic acid, madecassic acid)

Solubility: Glycosides dissolve in water phase; aglycones in oil phase (important for emulsion formulations)

Bioavailability: Glycosides are converted to aglycones in the gut (both forms needed for oral supplements)

Mechanism of Action: How TECA Works at Cellular Level

Pathway 1: Collagen Synthesis (Wound Healing)

Asiaticoside binds to fibroblast receptors

Activates TGF-β1 signaling cascade

Upregulates COL1A1 and COL3A1 genes (encode collagen I and III)

Increases procollagen production by 40-60% (measured in vitro)

Result: Faster wound closure, improved tensile strength

Pathway 2: Anti-Inflammatory Action

Madecassoside inhibits NF-κB nuclear translocation

Reduces pro-inflammatory cytokines:

IL-1β: -52% (p<0.001)

TNF-α: -48% (p<0.001)

IL-6: -38% (p<0.01)

Inhibits COX-2 and iNOS expression (inflammatory enzymes)

Result: Reduced redness, swelling, pain in inflamed skin

Pathway 3: Antioxidant Protection

Triterpenes donate electrons to free radicals (ROS scavenging)

Upregulate endogenous antioxidant enzymes:

SOD (superoxide dismutase): +35%

Catalase: +28%

Glutathione peroxidase: +31%

Protect against UV-induced oxidative damage (prevents photoaging)

Pathway 4: Neuroprotection & Cognitive Enhancement

1.Stimulates nerve growth factor (NGF) production in hippocampal neurons

2.Increases dendritic branching and synapse formation (neuroplasticity)

3.Protects neurons from β-amyloid toxicity (Alzheimer's mechanism)

4.Enhances acetylcholine levels (neurotransmitter for memory)

5.Result: Improved memory, learning, cognitive function

Clinical translation:

* Topical (0.5-2%): Wound healing, scar reduction, anti-aging

* Oral (300-750 mg/day): Cognitive enhancement, anxiety reduction, venous insufficiency

Our proprietary extraction process combines traditional herbal wisdom with modern pharmaceutical technology to achieve the highest purity and potency.

Step 1: Raw Material Sourcing & Authentication

Geographic origin: Madagascar (primary) + Sri Lanka (secondary)

Why these regions:

Optimal climate: Tropical wetlands with 2,000-3,000 mm annual rainfall

Soil quality: Rich in organic matter, low heavy metal contamination

Biodiversity: Wild-type Centella asiatica powder (not cultivated hybrids) with highest triterpene content

Harvesting protocol:

Timing: Harvest during vegetative growth phase (before flowering) when triterpene content peaks

Method: Hand-harvested aerial parts (leaves + stems, no roots)

Washing: Triple-washed with purified water to remove soil, insects

Drying: Shade-dried at 35-40°C (preserves heat-sensitive glycosides)

Botanical authentication:

Macroscopic identification: Kidney-shaped leaves, creeping stolons

Microscopic identification: Characteristic trichomes, vascular bundles

DNA barcoding: ITS2 and matK gene sequencing (confirms C. asiatica, rules out adulterants)

HPTLC fingerprinting: Matches reference standard from authenticated herbarium specimen

Quality control at source:

Heavy metal pre-screening (reject if Pb >1 ppm or Cd >0.2 ppm in dried herb)

Pesticide screening (test for 580+ compounds; must be <EU MRL limits)

Microbial testing (total count <10,000 CFU/g, no pathogens)

Step 2: Dual-Extraction Process

Phase 1: Water Extraction (Glycoside-Rich Fraction)

Purpose: Extract water-soluble triterpene glycosides (asiaticoside, madecassoside)

Comminution: Mill dried herb to 20-40 mesh (0.4-0.8 mm particle size)

Decoction:

Ratio: 1 kg herb : 10 L purified water

Temperature: 80-90°C (below boiling to prevent glycoside hydrolysis)

Time: 2 hours with gentle stirring

First extraction: Collect liquid, press marc

Second extraction: Add 8 L fresh water to marc, repeat 2-hour decoction

Combine extracts: Pool first and second extractions (total ~16 L)

Filtration: Pass through 100-mesh screen (removes particulates)

Yield: ~12% w/w (120g extract per kg dried herb)
Triterpene content: 15-20% (primarily glycosides)

Phase 2: Ethanol Extraction (Aglycone-Rich Fraction)

Purpose: Extract lipid-soluble triterpene aglycones (asiatic acid, madecassic acid) from the water-extracted marc

Solvent preparation: 70% ethanol (food-grade, non-GMO)

Percolation:

Pack water-extracted marc into percolation column

Slowly percolate 70% ethanol (1 L/hour flow rate)

Continue until eluate is colorless (typically 8-10 L per kg marc)

Concentration:

Vacuum evaporation at 50°C, <50 mbar pressure

Recover ethanol (92% recovery rate for reuse)

Concentrate to thick paste (40-50% solids)

Yield: ~5% w/w (50g extract per kg dried herb)
Triterpene content: 25-35% (primarily aglycones)

Phase 3: Combination & Standardization

Blend fractions: Mix water extract and ethanol extract in optimized ratio (typically 2:1)

HPLC analysis: Test for asiaticoside, madecassoside, asiatic acid, madecassic acid

Adjust ratio: Fine-tune blend to achieve TECA profile (40:30:29:1)

Spray-drying:

Inlet temperature: 180-200°C

Outlet temperature: 80-90°C

Carrier: Maltodextrin (5-10% for improved flow and stability)

Result: Fine powder, moisture <5%

Final yield: 8-10% w/w (80-100g TECA powder per kg dried herb)
Triterpene content: 80% minimum (HPLC-verified TECA profile)

Step 3: Purification & Decolorization

Challenge: Crude extract is dark green-brown (chlorophyll, tannins) and has bitter taste

Purification steps:

Activated carbon treatment:

Add 2-5% activated carbon to aqueous extract (before spray-drying)

Stir at 60°C for 30 minutes

Filter through 0.45 μm membrane

Result: Removes 85-90% of chlorophyll, 60-70% of tannins

Macroporous resin adsorption (optional, for ultra-pure grade):

Pass extract through AB-8 macroporous resin column

Wash with water (removes sugars, proteins)

Elute with 60% ethanol (collects triterpenes)

Result: 95%+ triterpene purity (pharmaceutical grade)

Membrane filtration:

Ultrafiltration (10 kDa cutoff) removes proteins, polysaccharides

Nanofiltration (1 kDa cutoff) concentrates triterpenes

Result: Clear, light-colored extract

Color specification:

Standard grade: Light tan to beige powder

Ultra-pure grade: Off-white to pale yellow powder

Step 4: Spray-Drying & Milling

Spray-drying parameters:

Atomizer: Centrifugal atomizer (20,000 RPM)

Feed rate: 5-8 L/hour

Inlet temperature: 180-200°C (high enough to evaporate water instantly)

Outlet temperature: 80-90°C (keeps product temperature <60°C, preserves triterpenes)

Cyclone separator: Captures fine particles (>95% collection efficiency)

Particle size control:

Standard: 80-100 mesh (150-180 μm) - good for capsules, tablets

Fine: 100-200 mesh (75-150 μm) - better for cosmetic emulsions

Micronized: 200-400 mesh (<75 μm) - enhanced bioavailability for oral supplements

Post-drying treatment:

Dehumidification: Pass through desiccant chamber (reduces moisture to <3%)

Sieving: Remove oversize particles

Metal detection: Inline metal detector (Fe: 0.5mm, Non-Fe: 1.0mm, SS: 1.5mm)

Nitrogen flushing: Package under nitrogen atmosphere (prevents oxidation)

Centella Asiatica Extract 80% TECA (Pharmaceutical Grade)

Centella Asiatica Extract 10% Total Triterpenes (Cosmetic Grade)

For customers requiring lower concentration (cost-effective for cosmetic applications):

Regulatory Compliance:

EU Cosmetics Regulation (EC) 1223/2009: Compliant (INCI: Centella Asiatica Extract)

China NMPA: IECIC listed (Inventory of Existing Cosmetic Ingredients in China)

US FDA: GRAS status for oral use (food supplement)

COSMOS/Ecocert: Approved for natural/organic cosmetics

Vegan: Certified (100% plant-derived, no animal testing)

Halal & Kosher: Certified

Centella triterpenes are relatively stable, but proper handling is critical for maintaining potency over shelf life.

Raw Material Stability (80% TECA Powder)

Long-term stability (ICH Zone II: 25°C / 60% RH):

Conclusion: Shelf life of 36 months when stored at ≤25°C in moisture-proof packaging (aluminum foil bag or HDPE drum with desiccant).

Accelerated stability (40°C / 75% RH):

Conclusion: Minimal degradation at accelerated conditions. Moisture uptake is primary concern (hygroscopic powder).

Formulation Stability: Critical Factors

Factor 1: pH Stability

Triterpene glycosides (asiaticoside, madecassoside) can hydrolyze at extreme pH:

Test protocol: 1% Centella extract in aqueous solution, 25°C, 3 months

Optimal pH range: 5.0-7.0 (suitable for most cosmetic and oral formulations)

Factor 2: Temperature Stability (Heat Processing)

Test protocol: 2% Centella extract exposed to various temperatures for 30 minutes

Formulation recommendation:

Cosmetics: Add Centella during cool-down phase (<60°C) after emulsification

Beverages: Add after pasteurization or use cold-fill process

Tablets/capsules: No heat exposure (direct encapsulation)

Factor 3: Light Stability (Photodegradation)

Test protocol: 2% Centella cream exposed to UV-A (320-400 nm, 10 W/m²) for 100 hours

Packaging recommendation: Use opaque or amber containers for Centella-containing products. If clear packaging is required (marketing), add UV filters (e.g., 0.5% benzophenone-4) or store in secondary opaque packaging.

Factor 4: Oxidation Stability

Triterpenes can oxidize in presence of oxygen and trace metals:

Test protocol: 2% Centella serum, 40°C, 3 months

Formulation recommendation:

Add 0.1% EDTA (chelates trace metals that catalyze oxidation)

Add 0.1-0.5% tocopherol (vitamin E) or 0.05% BHT (lipid-phase antioxidant)

Use nitrogen headspace in packaging (displaces oxygen)

Recommended Usage Levels by Application

Regulatory considerations:

EU (SCCS opinion): Safe up to 5% in leave-on cosmetics, 10% in rinse-off

US FDA: GRAS for oral use (no specific limit for supplements)

China NMPA: Maximum 2% in cosmetics (leave-on), 5% (rinse-off)

Formulation Strategies by Dosage Form

1. Cosmetic Serums (Water-Based)

Formulation example (2% Centella anti-aging serum, pH 5.5):

Phase A (Water Phase):

Deionized water: 82.5%

Glycerin: 5.0%

Propylene glycol: 3.0%

Centella extract (80% TECA): 2.0%

Phase B (Actives):

Niacinamide: 3.0%

Sodium hyaluronate (LMW): 1.0%

Panthenol: 1.0%

Phase C (Preservative & pH Adjustment):

Phenoxyethanol + ethylhexylglycerin: 1.0%

Citric acid: q.s. to pH 5.5

Sodium citrate: q.s. (buffer)

Process:

Dissolve Centella extract in water at room temperature (no heating required)

Add glycerin, propylene glycol, stir until homogeneous

Add Phase B ingredients one by one, stir gently (avoid foaming)

Add preservative

Adjust pH to 5.0-6.0 (optimal for Centella stability and skin compatibility)

Filter through 0.45 μm membrane (optional, for clarity)

Fill into airless pump bottles or amber glass bottles with dropper

Stability: 24 months at 25°C (with proper packaging)

2. Cosmetic Creams (Emulsion)

Formulation example (1.5% Centella anti-aging cream, O/W emulsion):

Phase A (Oil Phase, 20%):

Cetearyl alcohol: 4.0%

Cetearyl olivate + sorbitan olivate (natural emulsifier): 3.0%

Caprylic/capric triglyceride: 5.0%

Squalane: 3.0%

Tocopherol (vitamin E): 0.5%

Shea butter: 4.5%

Phase B (Water Phase, 75%):

Deionized water: 65.5%

Glycerin: 5.0%

Centella extract (80% TECA): 1.5%

Allantoin: 0.5%

Panthenol: 1.0%

Sodium hyaluronate: 0.5%

Phase C (Cool-Down Phase, 5%):

Niacinamide: 3.0%

Phenoxyethanol + ethylhexylglycerin: 1.0%

Xanthan gum: 0.3%

Citric acid: q.s. to pH 5.5

Fragrance (optional): 0.2%

Process:

Heat Phase A to 70-75°C, stir until fully melted

Heat Phase B to 70-75°C separately

Add Phase B to Phase A slowly with high-shear mixing (homogenizer, 3,000 RPM, 5 min)

Cool to 40°C with gentle stirring

Add Centella extract at 40°C (during cool-down to preserve triterpenes)

Add Phase C ingredients at 30-35°C

Adjust pH to 5.0-6.0

Fill into jars or tubes

Stability: 24-30 months at 25°C

3. Oral Capsules (Cognitive Enhancement)

Formulation example (500 mg Centella per capsule, size 0):

Ingredients per capsule:

Centella extract (80% TECA): 500 mg

Microcrystalline cellulose (MCC): 150 mg

Silicon dioxide (flow agent): 5 mg

Magnesium stearate (lubricant): 5 mg

Total fill weight: 660 mg

Capsule: HPMC (vegetarian) or gelatin, size 0 (holds up to 700 mg)

Process:

Blend Centella extract with MCC (geometric dilution for uniformity)

Add silicon dioxide, blend 5 minutes

Add magnesium stearate, blend 2 minutes (over-blending reduces disintegration)

Fill into capsules using automatic encapsulation machine

Polish to remove dust

Dosage: 1-2 capsules daily with meals (500-1,000 mg/day)

Stability: 24-36 months at 25°C in HDPE bottles with desiccant

4. Oral Tablets (Compressed)

Formulation example (300 mg Centella tablet, 600 mg total weight):

Ingredients:

Centella extract (80% TECA): 300 mg

Microcrystalline cellulose: 240 mg

Croscarmellose sodium (disintegrant): 30 mg

Polyvinylpyrrolidone K30 (binder): 20 mg

Magnesium stearate: 10 mg

Process:

Dry granulation (roller compaction) or direct compression

Blend all ingredients except magnesium stearate (15 min)

Add magnesium stearate, blend 2 min

Compress at 10-15 kN force

Film coating (optional):

HPMC-based coating (protects from moisture, improves swallowability)

Green color (matches Centella's herbal identity)

Disintegration time: <30 minutes (USP requirement)

Stability: 24-36 months in blister packs (PVC/PVDC/Al) or HDPE bottles

5. Functional Beverages

Formulation example (Cognitive health drink, 250 mL serving):

Ingredients per 250 mL:

Water: 230 mL

Centella extract (80% TECA): 500 mg (dissolved in 5 mL water)

Fruit juice concentrate (apple/grape): 10 mL

Natural flavor (citrus): 2 mL

Citric acid: 0.5 g (pH adjuster, preservative)

Sodium benzoate: 0.125 g (preservative)

Stevia extract: 0.05 g (sweetener)

L-theanine: 200 mg (synergistic cognitive enhancer)

Vitamin B complex: per RDA

Process:

Dissolve Centella extract in warm water (40°C), stir until clear

Add citric acid, sodium benzoate (adjust pH to 3.5-4.0 for preservation)

Add juice concentrate, flavor, sweetener

Add L-theanine, B vitamins

Fill into bottles, pasteurize (75°C, 15 min) or use aseptic filling

Note: Test Centella stability after pasteurization (should retain >95% TECA)

Shelf life: 12-18 months refrigerated (pasteurized), 24 months (aseptic)

Ingredient Compatibility Matrix

Synergistic Combinations (Enhanced Efficacy):

✓ Niacinamide (3-5%)

Mechanism: Both improve barrier function; niacinamide enhances ceramide synthesis

Formulation note: Fully compatible at pH 5-6; widely used in K-beauty

✓ Vitamin C (10-20% as ascorbic acid or derivatives)

Mechanism: Synergistic collagen synthesis; vitamin C is cofactor for prolyl hydroxylase

Formulation note: Use stable derivatives (ascorbyl glucoside, sodium ascorbyl phosphate) to avoid pH conflicts

✓ Peptides (Matrixyl, Argireline, 3-5%)

Mechanism: Complementary collagen stimulation pathways

Formulation note: Add peptides and Centella in same cool-down phase (<40°C)

✓ Hyaluronic Acid (0.5-2%)

Mechanism: Centella stimulates HAS2 (HA synthase); exogenous HA provides immediate hydration

Formulation note: Use multiple molecular weights for multi-layer hydration

✓ Retinol (0.25-1%)

Mechanism: Retinol boosts cell turnover; Centella soothes retinol irritation

Formulation note: Centella reduces retinoid dermatitis (redness, peeling)

✓ Azelaic Acid (10-20%)

Mechanism: Azelaic acid lightens PIH; Centella accelerates healing

Formulation note: Excellent for acne-prone skin (anti-inflammatory + antibacterial)

✓ Bacopa Monnieri (300 mg, oral)

Mechanism: Complementary nootropic pathways (Centella: NGF; Bacopa: serotonin)

Formulation note: Popular combination in Ayurvedic cognitive formulas

✓ Lion's Mane Mushroom (500 mg, oral)

Mechanism: Both stimulate NGF production via different pathways

Formulation note: Synergistic neuroprotection

Compatible (No Interaction):

✓ Sunscreen filters (physical & chemical)

No interaction; Centella enhances photoprotection

✓ AHAs/BHAs (glycolic acid, salicylic acid)

Compatible, but monitor pH (keep ≥3.5 for Centella stability)

✓ Ceramides, cholesterol, fatty acids

No interaction; barrier repair synergy

Incompatible/Problematic Combinations:

✗ Strong Oxidizing Agents (Benzoyl Peroxide >5%, Hydrogen Peroxide)

Risk: Oxidation of triterpenes (reduced efficacy)

Solution: Use in separate products (AM/PM regimen) or lower concentrations

⚠ Extremely Low pH (<3.0)

Risk: Glycoside hydrolysis (asiaticoside → asiatic acid)

Solution: Buffer formulations to pH ≥3.5; use aglycone-rich extracts for low-pH products

⚠ High Concentrations of Alcohol (>20%)

Risk: Drying effect counteracts Centella's barrier repair

Solution: Limit alcohol to <10% or use fatty alcohols (cetyl, stearyl)

JOYWIN own a number of invention patents and certifications including NOP/JAS, BRC, FSSC, cGMP, Kosher, HALAL, ISO9001, ISO14001, ISO22000, etc.

* Packaging: 1 kg / 5 kg in food-grade polyethylene bags, heat-sealed inside aluminum foil bags with desiccant. Packed in sturdy cardStandardboard cartons.

* Bulk Packaging: 10 kg or 25 kg in food-grade plastic pails or fiber drums with double liner for high-volume manufacturing.

* Storage: Store in a cool (<20°C), dry, dark place, away from strong odors. Keep container tightly sealed.

* Shelf Life: 24 months from the production date when stored under recommended conditions.

* Global Shipping: We manage reliable international logistics via air or sea freight, providing full documentation (COA, MSDS, Certificate of Origin, Phytosanitary Certificate). Samples are available for qualified B2B clients.

Q1: What is the difference between Centella Asiatica, Gotu Kola, and Bacopa monnieri?
A: Centella asiatica is the botanical name; Gotu Kola is its most common English name. It is distinct from Bacopa monnieri (Brahmi), another cognitive-support herb. While both support brain health, their primary active compounds and historical uses differ. Centella is notable for its dual skin-cognitive benefits and triterpenoid profile.

Q2: Is your extract safe for long-term use? Are there any contraindications?
A: Centella asiatica has an excellent safety profile with a long history of use. However, due to its potential effects on liver enzymes and sleep (high doses may cause drowsiness), it is often recommended to avoid concurrent use with sedative medications or hepatotoxic drugs. It is not recommended for pregnant or breastfeeding women without medical advice. Standardized extracts ensure consistent, safe dosing.

Q3: Do you offer a water-soluble version? Why is it important?
A: Yes, we offer a specialized water-soluble powder. The key triterpenoids are not naturally highly water-soluble. Our water-soluble grade uses advanced dispersion technology, making it ideal for clear beverages, instant drink mixes, and formulations where bioavailability and ease of use are critical.

Q4: What is the significance of standardizing to Madecassoside vs. Asiaticoside?
A: While both are important, the ratio can indicate an extract's primary focus. Higher Madecassoside is often sought for skin repair and anti-inflammatory applications. Balanced or higher Asiaticoside may be preferred for cognitive and neuroprotective formulations. Our standard extract provides a balanced, full-spectrum profile suitable for multi-benefit products.

Q5: What certifications do you provide?
A: Our product is manufactured in a cGMP and ISO 22000 certified facility. It is Kosher and Halal certified upon request. We provide Non-GMO statements and comprehensive Third-Party Laboratory Analysis Reports.

Q6: What is the recommended daily dosage in finished products?
A: Clinical studies on cognitive and skin benefits typically use doses equivalent to 300-600 mg of a standardized extract (containing ~8-10% total triterpenoids) per day, often split into two doses. We provide formulation support to determine the optimal inclusion rate for your target dosage.

Q7：Where & how can I place an order?
A：You can click the inquiry on Centella asiatica powder or send us an e-mail to contact@joywinworld.com.

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