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Products Description
Joywin Natural's Citrus Aurantium Extract Powder, derived from the ripe fruit of Citrus aurantium L. (Bitter Orange), represents a sophisticated, science-backed ingredient for the dietary supplement industry. Standardized to a consistent and potent 6% p-Synephrine content, our extract provides formulators with a reliable, bioactive core for products targeting metabolic rate, energy expenditure, and weight management support.
Unlike crude powders or non-standardized blends, our extract undergoes rigorous chromatographic processes to concentrate the primary active alkaloid-p-Synephrine-while carefully managing the levels of other adrenergic amines. This results in a high-purity, soluble powder that is manufactured under strict GMP guidelines, ensuring batch-to-batch consistency, safety, and compliance for our B2B partners integrating it into capsules, tablets, and functional beverage powders.
Product Source: Traceability from Grove to Extract
Quality and safety are rooted in our sourcing philosophy. We employ a vertically managed supply chain to guarantee botanical authenticity and purity.
* Botanical Identity: Citrus aurantium L. (Bitter Orange, Seville Orange). Identity is confirmed via macroscopic examination and TLC/HPLC fingerprinting against authentic reference material.
* Plant Part: Immature, dried fruit peel, scientifically known as Aurantii Fructus Immaturus or "Zhi Shi" in Traditional Chinese Medicine. This specific part is recognized for its concentrated synephrine content.
* Cultivation & Sourcing: Sourced from designated, pesticide-monitored orchards. We prioritize partners who employ Integrated Pest Management (IPM) practices. Full traceability documentation is maintained.
* Geographical Origin: Cultivated in regions with optimal growing conditions for Citrus aurantium, ensuring a robust phytochemical profile.
Product Composition & Standardization
This is a precisely quantified extract, standardized to its key active marker.
|
Component |
Category & Detail |
|
Primary Active Marker |
p-Synephrine (Synephrine): Standardized to 6.0% (w/w) minimum. This is the principal phenethylamine alkaloid responsible for the extract's primary physiological activity. |
|
Other Alkaloids (Carefully Controlled) |
Octopamine, N-Methyltyramine, Tyramine, hordenine. These are naturally present in the botanical but are monitored and controlled to low levels to ensure a clean, focused activity profile and enhance safety. |
|
Characteristic Flavonoids |
Hesperidin, Naringin, Neohesperidin. These bioactive flavonoids contribute antioxidant properties and are part of the extract's full-spectrum matrix. |
|
Extraction Solvent |
Ethanol-Water. A food-grade, clean solvent system preferred for extracting polar alkaloids and flavonoids. |
|
Carrier |
Maltodextrin (Non-GMO). Used as a drying agent to produce a stable, free-flowing, and readily soluble powder. |

Product Parameters & Certificate of Analysis (COA)
Each batch is released with a comprehensive COA, verifying compliance with our stringent specifications and relevant safety guidelines.
Typical Batch Specification Sheet:
|
Parameter |
Specification |
Test Method |
|
Product Name |
Citrus Aurantium Extract Powder |
- |
|
Botanical Name |
Citrus aurantium L. |
- |
|
Plant Part |
Immature Fruit Peel |
- |
|
Standardization |
p-Synephrine ≥ 6.0% |
HPLC-UV/PDA |
|
Key Alkaloid Limits |
||
|
Octopamine |
≤ 0.5% |
HPLC-UV/PDA |
|
N-Methyltyramine |
≤ 0.1% |
HPLC-UV/PDA |
|
Tyramine |
≤ 0.05% |
HPLC-UV/PDA |
|
Appearance |
Fine, light yellow to brown powder |
Visual |
|
Odor & Taste |
Characteristic citrus, slightly bitter |
Organoleptic |
|
Particle Size |
100% through 80 mesh |
Sieve Analysis |
|
Loss on Drying |
≤ 5.0% |
USP <731> |
|
Heavy Metals |
||
|
Lead (Pb) |
≤ 3.0 mg/kg |
ICP-MS |
|
Arsenic (As) |
≤ 2.0 mg/kg |
ICP-MS |
|
Cadmium (Cd) |
≤ 1.0 mg/kg |
ICP-MS |
|
Mercury (Hg) |
≤ 0.1 mg/kg |
ICP-MS |
|
Microbiology |
||
|
Total Plate Count |
< 10,000 CFU/g |
USP <2021> |
|
Yeast & Mold |
< 100 CFU/g |
USP <2021> |
|
E. Coli |
Negative |
USP <2022> |
|
Salmonella spp. |
Negative |
USP <2022> |
|
Solvent Residues (Ethanol) |
Complies with ICH Q3C, Class 3 |
GC |
|
Pesticide Residues |
Complies with USP <561> / EU MRLs |
LC-MS/MS/GC-MS/MS |
Production Process: Precision Extraction & Purification
Our process is engineered to isolate and standardize p-Synephrine effectively while controlling companion alkaloids.
1.Raw Material Preparation: Dried, milled bitter orange peel is authenticated and pre-tested for alkaloid profile.
2.Selective Extraction: The material undergoes dynamic maceration or percolation using a specified ethanol-water solvent, optimized for alkaloid yield.
3.Primary Concentration: The liquid extract is filtered and concentrated under vacuum at controlled low temperatures.
4.Purification & Enrichment: The concentrate undergoes a proprietary chromatographic purification step (e.g., resin adsorption) to enrich p-Synephrine and selectively reduce the levels of octopamine and other stimulating amines.
5.Standardization: The purified extract is analytically profiled and precisely adjusted to achieve the 6% p-Synephrine standardization.
6.Drying: The standardized liquid is spray-dried using non-GMO maltodextrin as a carrier, producing a homogenous, soluble powder.
7.Final Blending & QC: The powder is blended and subjected to full QC release testing.
Quality Control & Assurance: A Multi-Tiered Protocol
Our QC system is built on identity, purity, strength, and composition, ensuring every gram meets our high standards.
* Identity Confirmation: HPTLC and HPLC fingerprinting confirm botanical identity and authentic alkaloid profile against reference standards.
* Potency & Purity Verification: HPLC-UV/PDA is mandatory for quantifying p-Synephrine (6%) and controlling levels of octopamine, N-methyltyramine, and tyramine. This is our core differentiator.
* Comprehensive Contaminant Screening: Every batch is screened for heavy metals, pesticides, microbes, and solvent residues.
* Stability-Indicating Methods: Our HPLC methods are validated to monitor degradation, supporting real-time and accelerated shelf-life studies (typically 24 months).
* Documentation Transparency: We provide a complete Technical Dossier including COA, Method Validation Summaries, and Safety Data Sheets (SDS).
Product Features & Advantages
* Clinically Relevant Standardization: 6% p-Synephrine aligns with doses used in human studies, providing a reliable basis for product efficacy.
* High Purity & Selective Profile: Proprietary purification minimizes octopamine and other stimulatory amines, offering a cleaner, more focused activity profile compared to crude extracts.
* Superior Solubility & Flow: The spray-dried powder ensures excellent miscibility in dry blends and rapid dissolution in liquids.
* Safety by Design: Rigorous control of companion alkaloids addresses key safety concerns historically associated with bitter orange extracts.
* Regulatory Readiness: Comprehensive documentation supports NDI (New Dietary Ingredient) filings and regulatory compliance in major markets.
* Technical Partnership: We provide formulation guidance on recommended serving sizes and compatible ingredients.
Efficacy & Scientific Backing
p-Synephrine, the primary alkaloid in Citrus aurantium, has been the subject of numerous in vitro, animal, and human clinical studies focusing on its metabolic effects.
* Mechanism of Action: p-Synephrine is an adrenergic agonist with high selectivity for β-3 adrenergic receptors. This selectivity is key, as β-3 receptors are primarily involved in lipolysis (fat breakdown) and thermogenesis in adipose tissue, with minimal effects on β-1 (heart) and β-2 (smooth muscle, blood pressure) receptors compared to ephedrine. This may explain its favorable safety profile in clinical research.
* Clinical Research on Metabolic Rate & Weight Management: A notable 2011 review in Current Sports Medicine Reports concluded that p-Synephrine alone does not appear to have significant adverse effects on blood pressure or heart rate at commonly used doses (e.g., 10-50 mg) and may increase resting metabolic expenditure. Studies, including randomized controlled trials, have shown it can support increased energy expenditure, fat oxidation, and promote feelings of satiety as part of a weight management program.
* Sports Performance & Energy: Often included in pre-workout and energy formulas for its potential to enhance focus and energy levels without the jitteriness associated with high-caffeine or ephedrine-containing products.
* Critical Safety & Labeling Note: While our purified extract mitigates risks, responsible labeling is paramount. Products containing Citrus aurantium should advise consultation with a healthcare provider for individuals with hypertension, cardiac conditions, or those taking MAO inhibitors or stimulant medications. Transparency about the p-Synephrine content per serving is essential.
Disclaimer: Joywin Natural supplies this as a dietary ingredient. These statements refer to scientific research and have not been evaluated by the FDA/EFSA. This product is not intended to diagnose, treat, cure, or prevent any disease. Finished product claims are the brand's responsibility.
Application Scenarios & Formulation Ideas
Ideal for innovative brands in the metabolic health and performance nutrition categories.
* Weight Management Complexes: Core ingredient in capsules/tablets combined with green tea extract (EGCG), caffeine (from green coffee bean), cayenne pepper (capsaicin), and chromium.
* Thermogenic & Fat Burner Blends: Key component in multi-ingredient pre-workout or daily metabolic support formulas.
* Energy & Focus Supplements: Used alongside clean-source caffeine, L-Theanine, and B-vitamins for balanced energy without overstimulation.
* Sports Nutrition: Included in pre-workout powders or capsules to support energy and focus during training.
* Private Label/Contract Manufacturing: Full technical and regulatory support for your branded product line.
packaging & shipping
* Standard Packaging: 1 kg or 5 kg per food-grade polyethylene bag, sealed inside an aluminum foil bag with desiccant, placed in a sturdy carton. Packaging provides moisture and light protection.
* Storage: Store in a cool (below 25°C), dry, and well-ventilated area away from direct light. Keep container tightly sealed after opening.
* Shelf Life: 24 months from production date when stored in original, unopened packaging under recommended conditions.
* Shipping: Global shipping via air or sea. We provide all standard export documents: Commercial Invoice, Packing List, COA, Bill of Lading, Certificate of Origin, and SDS.

JOYWIN Technical support
● R&D team of 40 members to provide full technical support.
● Years of successful experience with top food companies in the world.
● Dedicate on build long-term relationships with our clients and developing deeps partnership.

FAQ
Q1: What is the typical serving size/dosage of p-Synephrine in finished products?
A: Clinical studies often use doses between 10 mg and 50 mg of p-Synephrine per day, typically divided into 2-3 doses. With our 6% extract, this translates to approximately 167 mg to 833 mg of extract powder per serving. We recommend starting at the lower end for formulation.
Q2: How does your 6% Synephrine extract differ from a 10:1 or 20:1 "bitter orange extract"?
A: Ratios (10:1) only indicate the amount of raw herb used, not the active compound content. Our 6% standardization guarantees a specific, measurable amount of p-Synephrine, ensuring consistent efficacy. Our extract is also purified to control other alkaloids, which ratio extracts do not specify.
Q3: Is Citrus Aurantium Extract safe?
A: When derived from a reputable supplier with controlled alkaloid profiles (like ours) and used at studied doses, the safety profile of p-Synephrine is considered favorable compared to older stimulants like ephedrine. However, it is not suitable for everyone. Appropriate label warnings are mandatory.
Q4: Do you offer other standardization levels (e.g., 4%, 10% Synephrine)?
A: Yes. We can customize extracts to various p-Synephrine concentrations (e.g., 4%, 8%, 10%) based on your formulation needs. Contact us to discuss custom projects.
Q5: What is your Minimum Order Quantity (MOQ)?
A: The standard MOQ is 10 kg. We offer sample quantities (100g-500g) for R&D and testing purposes.
Q6: Can you provide documentation for regulatory submissions (like an NDI in the USA)?
A: Yes. We provide a comprehensive Technical Dossier that includes full specifications, analytical methods, safety data (heavy metals, microbes), and stability information to support your regulatory filings.
Q7:Where & how can I place an order on Citrus Aurantium Extract Powder?
A:You can click the inquiry or send us an e-mail to contact@joywinworld.com
The company now has a professional Manufacturer Bulk Supply Citrus Aurantium Fruit Extract Powder production plant with complete inventory supply, timely delivery, considerate after-sales service, and reasonable prices. We continue to create value for our customers through the layout of multiple product lines, an operational network covering multiple regions of the world, and composite operational capabilities. The establishment of a perfect channel performance management system is helpful to improve the competitiveness and profitability of our company and bring high profit returns to our company.
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