Pure Quercetin Powder

Quercetin belongs to the flavonol subclass of flavonoids and is one of the most widespread and extensively studied flavonoids in nature. It is renowned for its potent antioxidant, anti-inflammatory, and immunomodulatory properties, earning it the reputation of being a "natural antihistamine" and a "multifunctional nutrient molecule." Over the past three decades, more than 20,000 studies on quercetin have been published on PubMed, making it one of the most scientifically documented plant compounds.

JOYWIN's Pure Quercetin Powder is produced from high-quality botanical sources using advanced extraction and purification technologies, designed to deliver a product with exceptional purity and bioactivity. As an innovation-driven biotechnology company founded in 2013, we apply the same rigorous quality control, GMP standards, and supply chain excellence that established us as the world's largest organic inulin manufacturer and one of the top four bromelain producers globally, ensuring this Quercetin Powder meets the highest specifications for purity, potency, and safety for your formulations.

The source of quercetin directly impacts its purity and quality. We select two primary botanical sources to ensure optimal raw material supply and product characteristics.

* Primary Source Options:

1. Sophora japonica Source: Our high-purity quercetin is primarily derived from the flower buds of the Styphnolobium japonicum (formerly Sophora japonica) tree, known as Huai Mi. These buds are a rich natural source of quercetin and its glycoside, rutin. By extracting rutin from the buds and then hydrolyzing it to remove the sugar moiety, high-purity quercetin aglycone is obtained. This source is renowned for producing high-purity products with low impurity profiles.

2. Oak Bark (Quercus spp.) Source: We also offer quercetin derived from oak bark, sourced from sustainably managed forests primarily in North America and Europe. Oak bark is rich in quercetin content, providing an alternative source for specific market needs.

* Sustainable Sourcing: We maintain long-term partnerships with certified suppliers to ensure sustainable and traceable raw material procurement. For the Sophora japonica source, we support sustainable harvesting practices that protect tree resources. For oak bark, we ensure it originates from forestry operations certified to Forest Stewardship Council (FSC) standards.

* Raw Material Verification: Each incoming batch of raw material undergoes rigorous identity verification, including macroscopic and microscopic identification, as well as HPTLC fingerprinting, to ensure species authenticity and purity.

The unique chemical structure of quercetin determines its broad range of biological activities. Understanding this structure helps clarify its mechanisms of action.

* Chemical Name & Structure: Quercetin is systematically named 3,3',4',5,7-pentahydroxyflavone. Its core structure is a flavone backbone (two benzene rings connected by an oxygen-containing heterocycle) with five hydroxyl (-OH) groups at key positions (3, 5, 7, 3', 4'). These hydroxyl groups are the primary contributors to its antioxidant activity.

* Molecular Forms:

- Quercetin Anhydrous: The form without water of crystallization.

- Quercetin Dihydrate: Contains two water molecules of crystallization and is the more common, stable form.

* Mechanisms of Bioactivity:

- Potent Antioxidant: The five hydroxyl groups enable it to effectively scavenge free radicals (such as superoxide anion, peroxynitrite) and chelate transition metal ions (such as iron, copper), thereby preventing oxidative damage.

- Signaling Pathway Modulator: Quercetin can modulate various cellular signaling pathways, including Nrf2 (antioxidant response element), NF-κB (nuclear factor kappa-B, a master switch for inflammation), and MAPK (mitogen-activated protein kinase) pathways, thereby exerting its anti-inflammatory and cytoprotective effects.

- Enzyme Inhibitor: It can inhibit the activity of multiple enzymes, including lipoxygenase (LOX), cyclooxygenase (COX), and certain kinases, which correlates with its anti-inflammatory effects.

* Appearance: A fine, yellow crystalline powder, odorless or nearly odorless.

Our manufacturing process is designed to extract, purify, and crystallize high-purity quercetin from natural sources, ensuring batch-to-batch consistency and high bioactivity. The following describes the Sophora japonica source process as an example.

1.Raw Material Receiving & Inspection: Procured Sophora japonica flower buds undergo rigorous inspection, including species identification, rutin content determination, and contaminant screening.

2.Rutin Extraction: The buds undergo hot water or hydroalcoholic extraction, followed by filtration, concentration, and cooling crystallization to obtain crude rutin. The crude rutin is purified by recrystallization to obtain high-purity rutin.

3.Hydrolysis: High-purity rutin is hydrolyzed under acidic conditions (e.g., dilute sulfuric acid) with heating. This process cleaves the glycosidic bond between quercetin and rutinose in the rutin molecule, releasing quercetin aglycone (insoluble in water) and rutinose (soluble in water).

4.Separation & Washing: Upon completion of hydrolysis, quercetin precipitates out. The crude quercetin is separated by filtration or centrifugation and washed repeatedly with hot water to remove acid and soluble sugars.

5.Purification & Recrystallization: The crude quercetin is dissolved in a suitable organic solvent (e.g., ethanol), subjected to decolorization treatment, and then recrystallized by controlled cooling. This critical step removes residual rutin, other flavonoid impurities, and hydrolysis by-products, significantly enhancing purity.

6.Drying & Milling: The pure quercetin crystals are vacuum-dried at low temperature (<60°C) to remove solvent and moisture, yielding dry crystals. Based on customer requirements, the dry product may be gently milled to achieve the desired particle size.

7.Screening & Blending: The powder is passed through vibratory sieves to ensure uniform particle size. Large batches are blended to guarantee homogeneity.

8.Final QC & Packaging: The finished powder is sampled and sent to our in-house laboratory for comprehensive analysis. Upon approval, it is packaged in sealed, food-grade containers in a clean area.

The purity of quercetin directly impacts its bioactivity and safety. Our quality control system, based on the global certification standards of our core products, ensures the product meets the most stringent international requirements.

* Raw Material Verification: Each incoming batch of raw material (Sophora japonica buds or oak bark) undergoes strict identity verification, including morphological identification and HPTLC fingerprinting, to confirm authenticity and screen for adulteration or substitutes.

* In-Process Monitoring: Parameters such as temperature, pH, time, and pressure are strictly monitored during critical steps like extraction, hydrolysis, recrystallization, and drying to ensure process stability and intermediate quality.

* Comprehensive Finished Product Testing (ISO 17025 Accredited Lab): Our in-house, ISO 17025-accredited laboratory is equipped with advanced HPLC, GC, and ICP-MS systems, performing full-spectrum testing on finished products:

- Assay & Purity: Precise determination of quercetin content and impurity profile using validated HPLC methods.

- Heavy Metal Analysis: Trace analysis of elements such as arsenic, lead, cadmium, and mercury using ICP-MS, ensuring levels are well below international limits.

- Residual Solvents: Testing for solvents potentially used in the production process according to USP <467> methods.

-Microbiological Safety: Comprehensive pathogen screening (Total Plate Count, Yeast/Mold, Salmonella, E. coli).

* Stability Studies: We conduct real-time and accelerated stability studies to determine optimal storage conditions and establish a reliable, guaranteed shelf life, typically 24-36 months.

* Certification Compliance: Our facilities and this product line comply with the international certifications held by our core products, including FSSC 22000, cGMP, ISO 9001, BRC, Kosher, and HALAL, ensuring our processes meet the highest global standards for safety and quality.

Choosing JOYWIN's Pure Quercetin Powder provides distinct benefits for your product development and brand reputation.

* Guaranteed High Purity (≥95%, ≥98%): Our advanced recrystallization process ensures a strictly controlled purity with high batch-to-batch consistency, providing a solid foundation for your formulations and efficacy research.

* Clear Impurity Profile: We not only provide the total assay but can also supply a detailed related substances profile upon request, ensuring complete transparency of product composition, which is critical for sensitive applications and research.

* Excellent Stability: Our product, thoroughly dried and properly packaged, exhibits excellent stability with a long shelf life under recommended storage conditions, facilitating inventory management and global shipping.

* Superior Processability: The fine crystalline powder with consistent particle size and good flowability ensures uniformity during capsule filling, tableting, and blending with other ingredients.

* Traceable Clean Source: We offer options from both Sophora japonica and oak bark sources and ensure full traceability from raw material procurement to finished product.

* Supply Chain Reliability: Leveraging our long-term relationships with global premium suppliers and our procurement capabilities as an industry leader, we guarantee a stable, reliable supply to meet your needs from R&D to large-scale production.

Quercetin is one of the most deeply studied compounds in phytochemical research, with its wide-ranging health benefits supported by a substantial body of scientific literature.

* Potent Antioxidant & Anti-inflammatory Effects:

- Mechanism: Quercetin exerts its antioxidant effects by directly scavenging free radicals, chelating metal ions, and activating endogenous antioxidant pathways (Nrf2). Its anti-inflammatory effects primarily occur through inhibition of key inflammatory signaling pathways such as NF-κB and MAPK, thereby reducing the production of pro-inflammatory cytokines (e.g., TNF-α, IL-6) and inflammatory mediators (e.g., prostaglandins, leukotrienes).

- Evidence: Numerous in vitro and in vivo studies have confirmed its antioxidant and anti-inflammatory capabilities. A review published in the journal Nutrients summarized the potential of quercetin in various inflammatory diseases (Reference: Nutrients, 2016).

* Immune Modulation & Anti-allergy:

- Mechanism: Quercetin is known as a "natural antihistamine" because it can stabilize mast cells, inhibiting their release of histamine and other allergic mediators. It can also modulate Th1/Th2 immune balance.

- Evidence: Clinical studies have shown that quercetin supplementation can reduce symptoms of seasonal allergies, such as sneezing, runny nose, and itchy eyes (Reference: Molecules, 2020).

* Cardiovascular Protection:

- Mechanism: Quercetin protects the cardiovascular system through multiple mechanisms, including improving vascular endothelial function, lowering blood pressure, inhibiting LDL oxidation, and reducing platelet aggregation.

- Evidence: A meta-analysis showed that quercetin supplementation significantly reduces blood pressure, especially in individuals with hypertension (Reference: Journal of the American Heart Association, 2016).

* Exercise Performance & Recovery:

- Mechanism: Its antioxidant and anti-inflammatory properties help reduce oxidative stress and muscle damage caused by intense exercise, potentially shortening recovery time.

- Evidence: Multiple studies suggest that quercetin supplementation can modestly improve endurance exercise performance and reduce post-exercise muscle soreness (Reference: Journal of the International Society of Sports Nutrition, 2010).

We ensure our high-purity quercetin reaches you in perfect condition, effectively protected from moisture and light.

* Standard Packaging:

- Inner: Double food-grade polyethylene (PE) bags, heat-sealed for moisture protection.

- Outer: Sealed, moisture-proof fiber drum.

- Net Weight: Typically 25kg/drum. Smaller quantities (1kg-5kg) available in sealed aluminum foil bags.

* Storage Conditions: Store in a cool, dry place, away from direct sunlight and strong odors. Keep container tightly closed when not in use. Under these conditions, shelf life is typically 24-36 months.

* Logistics & Shipping:

- Port of Loading: Shanghai / Chongqing, China.

- Lead Time: 3-5 business days for stock items.

- Shipping Options: Air freight, sea freight (FCL/LCL), and international express (DHL/FedEx/UPS) for sample or urgent orders.

- Documentation: Full set provided: Commercial Invoice, Packing List, COA, Bill of Lading/Air Waybill, Certificate of Origin, and any other necessary documentation.

JOYWIN own a number of invention patents and certifications including NOP/JAS, BRC, FSSC, cGMP, Kosher, HALAL, ISO9001, ISO14001, ISO22000, etc.

As customer focus has never been so important for today's enterprises, we believe that only a customer-focused company will win renewed loyalty and competitive advantage.
At JOYWIN, Our team of professionals is committed to providing superior and personalized service to meet all your needs.

Q1: What is the difference between quercetin anhydrous and dihydrate? How should I choose?
A1: The main difference lies in the presence of water of crystallization. The dihydrate form contains two water molecules and is the more common and naturally occurring form, typically stable under ambient conditions. The anhydrous form contains no water of crystallization. For most supplement applications, either form can be used, but dosage adjustments based on molar mass may be necessary (the anhydrous form has slightly higher potency). We can supply both forms and offer guidance based on your formulation needs.

Q2: Is your quercetin synthetic or natural?
A2: Our quercetin is natural in origin, primarily extracted and purified from Sophora japonica flower buds or oak bark (Quercus spp.). We provide transparent information regarding the specific botanical source.

Q3: Quercetin is known to have low bioavailability. Do you have any suggestions or related products?
A3: Yes, quercetin's low water solubility and first-pass metabolism do impact its bioavailability. Common solutions include formulating with other bioavailability enhancers (e.g., black pepper extract, bromelain), or using specialized delivery forms (e.g., phytosomes, cyclodextrin complexes, liposomes). We can offer general advice on these strategies and can explore the possibility of developing specific delivery forms in the future.

Q4: Can you provide samples for R&D purposes?
A4: Absolutely. We provide complimentary samples (50g-100g) for qualified B2B clients. Please contact us with your requirements and intended application.

Q5: Are your products suitable for vegetarians and vegans?
A5: Yes, our Quercetin Powder is 100% plant-based and suitable for vegetarian and vegan formulations.

Q6: How do you ensure that your quercetin is free from residual rutin or other impurities?
A6: Our HPLC analytical method is capable of fully separating quercetin, rutin, and other related flavonoids. Our product specifications strictly control individual unspecified impurities and total impurities. A detailed impurity profile can be provided in the COA upon request, ensuring that residual raw materials such as rutin are well below acceptable limits.

Q7：How can we contact you?
A7：You can click the inquiry on Pure quercetin powder or send us an e-mail to contact@joywinworld.com.

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