Products Description
Natto Extract is a highly concentrated, bioactive ingredient derived from natto-a traditional Japanese food made from soybeans fermented with Bacillus subtilis var. natto. This potent extract delivers standardized levels of Nattokinase, a powerful fibrinolytic enzyme, and Vitamin K2 (Menaquinone-7, MK-7), making it an unparalleled ingredient for cardiovascular and bone health formulations.
As a leading B2B supplier, we provide a scientifically-backed, all-natural extract that allows supplement manufacturers to offer clinically relevant doses of these key bioactives in convenient capsule, tablet, or powder form. Our product is meticulously processed to ensure optimal enzyme activity and nutrient stability, providing your end-products with proven efficacy and market differentiation.
Product Source & Traceability
Authentic Japanese Fermentation Heritage
Authenticity is paramount. Our extract begins with non-GMO soybeans cultivated in designated regions, fermented using a proprietary strain of Bacillus subtilis var. natto to ensure a high yield of Nattokinase and Vitamin K2.
* Base Ingredient: Select, non-GMO Japanese soybeans (Glycine max)
* Fermentation Strain: Bacillus subtilis var. natto
* Fermentation Process: Traditional solid-state fermentation under controlled conditions
* Quality Assurance: Raw material identity verified via genomic testing; sourced from trusted agricultural partners with full traceability.
Key Active Composition
Our Natto Extract is standardized to guarantee potent and consistent levels of its two primary bioactive compounds.
|
Active Compound |
Specification |
Biological Significance |
|
Nattokinase Activity |
≥ 20,000 FU/g (Fibrinolytic Units) |
A potent fibrinolytic enzyme that supports healthy blood flow and circulation by breaking down fibrin. |
|
Vitamin K2 (as MK-7) |
≥ 100 mcg/g |
The most bioavailable form of Vitamin K2, crucial for directing calcium to the bones and teeth and away from the arteries. |

Product Specifications & Certificate of Analysis (COA)
Every batch is verified through rigorous third-party testing, with a comprehensive COA provided to ensure compliance with your quality standards.
Typical Specification Sheet:
|
Parameter |
Specification |
Test Method |
|
Appearance |
Fine, light yellow to tan powder |
Visual |
|
Odor & Taste |
Characteristic, slightly fermented odor |
Organoleptic |
|
Assay |
Nattokinase ≥ 20,000 FU/g |
Enzymatic / HPLC |
|
Mesh Size |
100% pass 80 mesh |
Sieve Analysis |
|
Loss on Drying |
≤ 6.0% |
Karl Fischer |
|
Total Plate Count |
< 10,000 CFU/g |
USP <61> |
|
Yeast & Mold |
< 100 CFU/g |
USP <61> |
|
E. Coli |
Negative |
USP <62> |
|
Salmonella |
Negative |
USP <62> |
|
Staphylococcus aureus |
Negative |
USP <62> |
|
Heavy Metals |
||
|
Lead (Pb) |
< 2 mg/kg |
ICP-MS |
|
Arsenic (As) |
< 1 mg/kg |
ICP-MS |
|
Cadmium (Cd) |
< 0.5 mg/kg |
ICP-MS |
|
Mercury (Hg) |
< 0.1 mg/kg |
ICP-MS |
Manufacturing Process & Quality Control
Precision Fermentation and Gentle Extraction for Maximum Bioactivity
Our state-of-the-art process is designed to preserve the delicate enzymatic activity of Nattokinase while concentrating Vitamin K2.
* Selection & Preparation: High-quality, non-GMO soybeans are carefully selected, washed, and soaked.
* Sterilization & Inoculation: Soybeans are steamed and inoculated with a pure, proprietary culture of Bacillus subtilis var. natto.
* Controlled Fermentation: The inoculated beans undergo solid-state fermentation in climate-controlled chambers for optimal enzyme and vitamin production.
* Post-fermentation Processing: The fermented natto is harvested and undergoes a low-temperature extraction process to create a concentrated slurry.
* Spray Drying: The slurry is dried using low-temperature spray drying to preserve the activity of heat-sensitive Nattokinase.
* Standardization & Blending: The final powder is standardized to guaranteed activity levels of Nattokinase and Vitamin K2 and blended for batch-to-batch consistency.
* Quality Control: Our facilities operate under cGMP and are FSSC 22000 certified. Every batch undergoes in-process and final quality checks, including activity assays.
Product Features & Key Advantages
* Dual-Action Formulation: Provides two of the most sought-after nutrients from natto in a single, potent extract.
* Standardized Potency: Guaranteed high activity levels of Nattokinase (≥ 20,000 FU/g) and Vitamin K2 (MK-7 ≥ 100 mcg/g) for reliable efficacy.
* All-Natural & Clean-Label: Derived solely through fermentation and physical processing-no synthetic solvents used.
* Stable & Bioavailable: Our low-temperature drying process ensures enzyme stability, and the MK-7 form of Vitamin K2 offers a long half-life for sustained benefits.
* Third-Party Verified: All activity and purity claims are backed by independent laboratory testing.
Scientifically Supported Health Benefits
The benefits of natto's key components are supported by a growing body of clinical research.
* Cardiovascular & Circulatory Health: Nattokinase has been shown to support healthy blood flow and circulation by directly breaking down fibrin, a key protein in blood clots. [Reference: Hypertension Research, 2008].
* Bone Health & Calcium Utilization: Vitamin K2 (MK-7) activates osteocalcin, a protein that binds calcium into the bone matrix, supporting bone density. It also helps inhibit arterial calcification. [Reference: Osteoporosis International, 2013].
* Antioxidant & Anti-inflammatory Properties: The fermentation process produces other bioactive peptides and compounds that exhibit antioxidant and anti-inflammatory activities.
Product Applications
Our Natto Extract Powder is ideal for a range of advanced health products:
* Cardiovascular Supplements: Targeted formulas for circulatory and heart health, often combined with other supporting nutrients like CoQ10 or Aged Garlic Extract.
* Bone & Joint Health Formulas: Combined with Calcium, Vitamin D3, and Magnesium for comprehensive skeletal support, particularly for post-menopausal women.
* General Wellness Supplements: Incorporated into daily multivitamin or senior health formulas.
* Functional Foods: Can be microencapsulated for inclusion in specialized functional food products (subject to regional regulations).
Packaging & Logistics
We ensure the stability and integrity of your product from our facility to yours.
* Standard Packaging: 1 kg per aluminum foil bag, vacuum-sealed. 10-20 kg per carton/drum.
* Custom Packaging: Available upon request.
* Storage: Store in a cool (< 20°C), dry place, protected from light and moisture.
* Shelf Life: 24 months when stored properly in unopened packaging.
* Global Shipping: We offer reliable global logistics solutions with flexible terms (FOB, CIF, DAP) to meet your supply chain needs.
JOYWIN Manufacturing Facilities
JOYWIN founded in 2013 is an innovation-driven biotechnology company. we provide the manufacture of plant extracts, plant proteases, and customized products. We believe Good produce= Integrity+ Technology+Quality Control.

JOYWIN Exhibition Show
JOYWIN attend international exhibitions, including CPhI, FIC, API, Vitafoods, SupplesideWest.

FAQ
Q1: What is the recommended dosage for a finished supplement?
A: Clinical studies on Nattokinase often use doses of 100-200 mg of extract standardizing to 2,000 FU (Fibrinolytic Units) per day. For Vitamin K2 (MK-7), common doses range from 90-180 mcg daily. Our technical team can help you calculate the appropriate inclusion rate for your desired dosage.
Q2: Are there any contraindications for Nattokinase?
A: Yes. As a fibrinolytic agent, it should not be used by individuals with bleeding disorders, those taking anticoagulant or antiplatelet medications (e.g., Warfarin, Aspirin), or before surgery. It is crucial to include appropriate disclaimer language on your product labels.
Q3: Is this product non-GMO and allergen-free?
A: The extract is derived from non-GMO soybeans. However, as a soybean product, it contains soy allergens. We provide full allergen statements and non-GMO documentation.
Q4: Can you supply different standardizations of Nattokinase and Vitamin K2?
A: Absolutely. We offer custom extraction and blending services to achieve specific ratios and potencies tailored to your formulation needs.
Q5: What documentation do you provide?
A: We provide a comprehensive suite of documents, including Certificate of Analysis (COA), Allergen Statement, Non-GMO Certificate, and Shelf-Life Report. Technical dossiers are available for regulatory support.
Q6:How could I place an order?
A:You can click the inquiry on Natto extract or send us an e-mail to contact@joywinworld.com.
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